Binding Scores

These are the computed outputs of the data labeling pipeline.

File: binding-scores-YYYYMMDD.parquet Aggregated binding scores per candidate and antigen pair. Replicate binding scores are averaged across replicates and pivoted so that each antigen concentration becomes its own column. Grain: one row per unique (candidate_id, sino_catalog_id).

Fixed Columns

Column	Type	Description
`candidate_library_id`	`string`	Identifier of the candidate library consumed by this sample.
`candidate_name`	`string`	Customer-provided sequence name.
`candidate_id`	`string`	Blake-3 content digest of the reference sequence.
`candidate_sequence`	`string`	The candidate amino acid sequence.
`variant_id`	`string`	Blake-3 content digest of the variant sequence.
`variant_sequence`	`string`	The variant sequence.
`sino_catalog_id`	`string`	Sino catalog identifier for the antigen used in the binding assay.
`antigen_gene_name`	`string`	Gene name of the antigen.
`antigen_sequence`	`string`	Amino acid sequence of the antigen.
`targeting`	`boolean`	Whether the candidate was designed to target this antigen.
`is_expressed`	`boolean`	Whether the candidate is expressed in at least one sample.

Dynamic Concentration Columns

In addition to the fixed columns above, this table contains dynamic columns for each antigen concentration used in the experiment. The column names follow the pattern binding_score_{conc}nM and binding_score_{conc}nM_std.

For example, if the experiment used concentrations of 10 nM, 50 nM, and 200 nM, you will see these additional columns:

Column	Type	Description
`binding_score_10nM`	`float`	Mean log binding score at 10 nM.
`binding_score_10nM_std`	`float`	Standard deviation of the log binding score at 10 nM.
`binding_score_50nM`	`float`	Mean log binding score at 50 nM.
`binding_score_50nM_std`	`float`	Standard deviation of the log binding score at 50 nM.
`binding_score_200nM`	`float`	Mean log binding score at 200 nM.
`binding_score_200nM_std`	`float`	Standard deviation of the log binding score at 200 nM.

Replicate Binding Scores

File: replicate-binding-scores-YYYYMMDD.parquet Per-replicate binding scores unrolled across antigen concentrations. Each row represents a single candidate measured in a specific expression/binding sample pair at a specific antigen concentration. Use this table to inspect replicate-level variation and per-sample UMI counts. Grain: one row per (candidate_id, binding_sample_id, antigen_concentration_nM).

Column	Type	Nullable	Description
`candidate_library_id`	`string`	no	Identifier of the candidate library consumed by this sample.
`expression_sample_id`	`string`	no	Sample identifier for the expression (base) sample.
`binding_sample_id`	`string`	no	Sample identifier for the binding (dose) sample.
`candidate_name`	`string`	no	Customer-provided sequence name.
`candidate_id`	`string`	no	Blake-3 content digest of the reference sequence.
`candidate_sequence`	`string`	no	The candidate amino acid sequence.
`variant_id`	`string`	no	Blake-3 content digest of the variant sequence.
`variant_sequence`	`string`	no	The variant sequence.
`sino_catalog_id`	`string`	no	Sino catalog identifier for the antigen.
`antigen_gene_name`	`string`	no	Gene name of the antigen.
`antigen_sequence`	`string`	no	Amino acid sequence of the antigen.
`antigen_concentration_nM`	`float`	no	Antigen concentration in nanomolar.
`targeting`	`boolean`	no	Whether the candidate was designed to target this antigen.
`is_expressed`	`boolean`	no	Whether the candidate is expressed.
`binding_score`	`float`	yes	Log binding score. Null when UMI count thresholds are not met.
`expression_umi_count`	`integer`	yes	UMI count from the expression (base) sample.
`binding_umi_count`	`integer`	yes	UMI count from the binding (dose) sample.

Key relationships:

expression_sample_id and binding_sample_id both correspond to dim_samples.sample_id.
candidate_id is the shared candidate key across all tables.

Dataset Guide

Resources

Binding Scores

Binding Scores

Fixed Columns

Dynamic Concentration Columns

Replicate Binding Scores

​Binding Scores

​Fixed Columns

​Dynamic Concentration Columns

​Replicate Binding Scores

Binding Scores

Fixed Columns

Dynamic Concentration Columns

Replicate Binding Scores